今年冬天,具有超強(qiáng)傳染力的新冠病毒奧密克戎變異毒株在美國(guó)肆虐。雖然感染者數(shù)量的激增突如其來(lái),,并且異常猛烈,,但專家表示,許多接種過疫苗的人感染了新冠病毒,,或許能夠幫助形成許多科學(xué)家所說(shuō)的“超級(jí)免疫力”,。
美國(guó)俄勒岡健康與科學(xué)大學(xué)(Oregon Health & Science University)的研究人員在2021年12月發(fā)表的一篇論文指出,超級(jí)免疫力是指接種過新冠疫苗的患者在突破性感染后產(chǎn)生強(qiáng)烈的免疫反應(yīng),。該大學(xué)于今年1月下旬發(fā)表的后續(xù)研究論文稱,,疫苗免疫與自然免疫相結(jié)合給患者提供的保護(hù)力,無(wú)論哪一種免疫先出現(xiàn),,都高于單純一種免疫的保護(hù)力,。
俄勒岡健康與科學(xué)大學(xué)醫(yī)學(xué)院(OHSU School of Medicine)的分子微生物學(xué)與免疫學(xué)教授、論文的作者之一菲卡杜·塔菲斯說(shuō):“無(wú)論是先感染后接種疫苗,,還是接種疫苗后經(jīng)歷突破性感染,,都沒有影響?!?/p>
不過,,該大學(xué)最新研究的患者數(shù)量相對(duì)較少,只有104名接種過輝瑞(Pfizer)疫苗的該校員工參與了研究,。但哥倫比亞大學(xué)梅爾曼公共衛(wèi)生學(xué)院(Columbia Mailman School of Public Health)的醫(yī)學(xué)和流行病學(xué)副教授杰西卡·賈斯特曼博士告訴《財(cái)富》雜志,,最近在南非也發(fā)現(xiàn)了“超級(jí)免疫力”現(xiàn)象。
換言之,,這些仍然是初步研究結(jié)果,,而且許多專家需要尋找更多的數(shù)據(jù)才可以得出具體結(jié)論。沒有人應(yīng)該為了提高免疫力故意感染新冠病毒,。賈斯特曼稱:“我能夠理解這兩項(xiàng)研究的結(jié)果,,但我們需要更多的時(shí)間來(lái)證明它會(huì)得到普遍認(rèn)可?!?/p>
美國(guó)得克薩斯大學(xué)休斯頓健康科學(xué)中心(University of Texas Health Science Center at Houston)麥戈文醫(yī)學(xué)院(McGovern Medical School)的傳染病系主任劉易斯·奧斯特羅斯基表示,,初步研究證明,疫苗和自然感染新冠產(chǎn)生的抗體所提供的保護(hù)力,,高于多次自然感染新冠產(chǎn)生的抗體的保護(hù)力,,這個(gè)結(jié)論依舊是有幫助的。這是因?yàn)?,感染新冠產(chǎn)生的抗體,,由于人體免疫系統(tǒng)的差異會(huì)有所不同。
奧斯特羅斯基告訴《財(cái)富》雜志:“某些人在某些時(shí)候會(huì)因?yàn)樽匀桓腥径a(chǎn)生強(qiáng)大的免疫力,,但它并不持久,?!彼赋觯@種免疫力通常只會(huì)持續(xù)三個(gè)月,。有些人在感染新冠病毒之后并沒有產(chǎn)生免疫力,。
“我們?cè)谝咔橹幸娺^有人感染了每一種變種病毒,因?yàn)橛行┤藦奈串a(chǎn)生過免疫力,,或者免疫力持續(xù)時(shí)間較短并且不可靠,。”
因此,,奧斯特羅斯基表示,,大部分醫(yī)學(xué)專家一直認(rèn)為接種疫苗是產(chǎn)生免疫力最好的途徑。接種疫苗不僅可以減少住院和死亡人數(shù),,而且事實(shí)證明通過疫苗和突破性感染所產(chǎn)生的混合免疫力,,比單純通過自然感染獲得的免疫力更強(qiáng)大,。
奧斯特羅斯基稱:“對(duì)于奧密克戎疫情,,許多人都有一種復(fù)雜的感覺,因?yàn)轱@而易見,,確實(shí)有很多人感染,,而且單從絕對(duì)數(shù)來(lái)看,有許多人不得不住院甚至死去,,但這種情況正在形成我們的群體免疫力,。”
妙佑醫(yī)療國(guó)際(Mayo Clinic)認(rèn)為,,要達(dá)到群體免疫并成功阻止病毒傳播,,必須有約94%的人產(chǎn)生免疫力。隨著奧密克戎感染者以驚人的速度增加,,健康專家們相信美國(guó)可能正在實(shí)現(xiàn)群體免疫的目標(biāo),,但有專家認(rèn)為,即使形成了群體免疫也可能無(wú)法持續(xù)太長(zhǎng)時(shí)間,。
一定程度的群體免疫非常重要,,可以幫助美國(guó)的新冠疫情從大流行階段演變成地方性流行病,因?yàn)榇蠖鄶?shù)人至少暫時(shí)對(duì)新冠病毒產(chǎn)生了免疫力,,生活能夠恢復(fù)常態(tài),。
但賈斯特曼認(rèn)為,重要的是要記住,,一個(gè)人要想產(chǎn)生“超級(jí)免疫力”,,就必須在突破性感染之后活下來(lái)。尤其是對(duì)老年人和既有病癥患者而言,,突破性感染確實(shí)存在危險(xiǎn),。
她補(bǔ)充道:“即便是突破性感染后存活下來(lái)的人,,大部分都要承受嚴(yán)重急性癥狀和/或長(zhǎng)期癥狀的折磨?!?/p>
俄勒岡健康與科學(xué)大學(xué)研究的作者認(rèn)為,,即使病毒持續(xù)變異,超級(jí)免疫力對(duì)于未來(lái)可能出現(xiàn)的其他變異株依舊有效,。但隨著更多的數(shù)據(jù)出現(xiàn),,超級(jí)免疫力的保護(hù)力可能會(huì)有所變化。
奧斯特羅斯基說(shuō):“我希望所有人都明白,,你不能為了獲得混合免疫力而故意感染病毒,。這是一種非常危險(xiǎn)的做法。畢竟新冠肺炎能夠致命,,如果你故意感染病毒,,就沒有任何人可以保證你安然無(wú)恙?!保ㄘ?cái)富中文網(wǎng))
翻譯:劉進(jìn)龍
審校:汪皓
今年冬天,,具有超強(qiáng)傳染力的新冠病毒奧密克戎變異毒株在美國(guó)肆虐。雖然感染者數(shù)量的激增突如其來(lái),,并且異常猛烈,,但專家表示,許多接種過疫苗的人感染了新冠病毒,,或許能夠幫助形成許多科學(xué)家所說(shuō)的“超級(jí)免疫力”,。
美國(guó)俄勒岡健康與科學(xué)大學(xué)(Oregon Health & Science University)的研究人員在2021年12月發(fā)表的一篇論文指出,超級(jí)免疫力是指接種過新冠疫苗的患者在突破性感染后產(chǎn)生強(qiáng)烈的免疫反應(yīng),。該大學(xué)于今年1月下旬發(fā)表的后續(xù)研究論文稱,,疫苗免疫與自然免疫相結(jié)合給患者提供的保護(hù)力,無(wú)論哪一種免疫先出現(xiàn),,都高于單純一種免疫的保護(hù)力,。
俄勒岡健康與科學(xué)大學(xué)醫(yī)學(xué)院(OHSU School of Medicine)的分子微生物學(xué)與免疫學(xué)教授、論文的作者之一菲卡杜·塔菲斯說(shuō):“無(wú)論是先感染后接種疫苗,,還是接種疫苗后經(jīng)歷突破性感染,,都沒有影響?!?/p>
不過,,該大學(xué)最新研究的患者數(shù)量相對(duì)較少,只有104名接種過輝瑞(Pfizer)疫苗的該校員工參與了研究,。但哥倫比亞大學(xué)梅爾曼公共衛(wèi)生學(xué)院(Columbia Mailman School of Public Health)的醫(yī)學(xué)和流行病學(xué)副教授杰西卡·賈斯特曼博士告訴《財(cái)富》雜志,,最近在南非也發(fā)現(xiàn)了“超級(jí)免疫力”現(xiàn)象。
換言之,,這些仍然是初步研究結(jié)果,,而且許多專家需要尋找更多的數(shù)據(jù)才可以得出具體結(jié)論,。沒有人應(yīng)該為了提高免疫力故意感染新冠病毒。賈斯特曼稱:“我能夠理解這兩項(xiàng)研究的結(jié)果,,但我們需要更多的時(shí)間來(lái)證明它會(huì)得到普遍認(rèn)可,。”
美國(guó)得克薩斯大學(xué)休斯頓健康科學(xué)中心(University of Texas Health Science Center at Houston)麥戈文醫(yī)學(xué)院(McGovern Medical School)的傳染病系主任劉易斯·奧斯特羅斯基表示,,初步研究證明,,疫苗和自然感染新冠產(chǎn)生的抗體所提供的保護(hù)力,高于多次自然感染新冠產(chǎn)生的抗體的保護(hù)力,,這個(gè)結(jié)論依舊是有幫助的,。這是因?yàn)椋腥拘鹿诋a(chǎn)生的抗體,,由于人體免疫系統(tǒng)的差異會(huì)有所不同,。
奧斯特羅斯基告訴《財(cái)富》雜志:“某些人在某些時(shí)候會(huì)因?yàn)樽匀桓腥径a(chǎn)生強(qiáng)大的免疫力,但它并不持久,?!彼赋觯@種免疫力通常只會(huì)持續(xù)三個(gè)月,。有些人在感染新冠病毒之后并沒有產(chǎn)生免疫力,。
“我們?cè)谝咔橹幸娺^有人感染了每一種變種病毒,因?yàn)橛行┤藦奈串a(chǎn)生過免疫力,,或者免疫力持續(xù)時(shí)間較短并且不可靠?!?/p>
因此,,奧斯特羅斯基表示,大部分醫(yī)學(xué)專家一直認(rèn)為接種疫苗是產(chǎn)生免疫力最好的途徑,。接種疫苗不僅可以減少住院和死亡人數(shù),,而且事實(shí)證明通過疫苗和突破性感染所產(chǎn)生的混合免疫力,比單純通過自然感染獲得的免疫力更強(qiáng)大,。
奧斯特羅斯基稱:“對(duì)于奧密克戎疫情,,許多人都有一種復(fù)雜的感覺,因?yàn)轱@而易見,,確實(shí)有很多人感染,,而且單從絕對(duì)數(shù)來(lái)看,有許多人不得不住院甚至死去,,但這種情況正在形成我們的群體免疫力,。”
妙佑醫(yī)療國(guó)際(Mayo Clinic)認(rèn)為,,要達(dá)到群體免疫并成功阻止病毒傳播,,必須有約94%的人產(chǎn)生免疫力,。隨著奧密克戎感染者以驚人的速度增加,健康專家們相信美國(guó)可能正在實(shí)現(xiàn)群體免疫的目標(biāo),,但有專家認(rèn)為,,即使形成了群體免疫也可能無(wú)法持續(xù)太長(zhǎng)時(shí)間。
一定程度的群體免疫非常重要,,可以幫助美國(guó)的新冠疫情從大流行階段演變成地方性流行病,,因?yàn)榇蠖鄶?shù)人至少暫時(shí)對(duì)新冠病毒產(chǎn)生了免疫力,生活能夠恢復(fù)常態(tài),。
但賈斯特曼認(rèn)為,,重要的是要記住,一個(gè)人要想產(chǎn)生“超級(jí)免疫力”,,就必須在突破性感染之后活下來(lái),。尤其是對(duì)老年人和既有病癥患者而言,突破性感染確實(shí)存在危險(xiǎn),。
她補(bǔ)充道:“即便是突破性感染后存活下來(lái)的人,,大部分都要承受嚴(yán)重急性癥狀和/或長(zhǎng)期癥狀的折磨?!?/p>
俄勒岡健康與科學(xué)大學(xué)研究的作者認(rèn)為,,即使病毒持續(xù)變異,超級(jí)免疫力對(duì)于未來(lái)可能出現(xiàn)的其他變異株依舊有效,。但隨著更多的數(shù)據(jù)出現(xiàn),,超級(jí)免疫力的保護(hù)力可能會(huì)有所變化。
奧斯特羅斯基說(shuō):“我希望所有人都明白,,你不能為了獲得混合免疫力而故意感染病毒,。這是一種非常危險(xiǎn)的做法。畢竟新冠肺炎能夠致命,,如果你故意感染病毒,,就沒有任何人可以保證你安然無(wú)恙?!保ㄘ?cái)富中文網(wǎng))
翻譯:劉進(jìn)龍
審校:汪皓
The contagious Omicron COVID variant has run rampant through the U.S. this winter. And although the infection spike was sudden and intense, experts say the fact that so many vaccinated people have come down with COVID might help build what some scientists are calling “super immunity.”
Super immunity refers to what happens when a vaccinated COVID patient has a strong immune response following a breakthrough infection, according to a study released in December by researchers at the Oregon Health & Science University. The combination of vaccine immunity and natural immunity—no matter in what order it occurs—gives people more protection than someone who had just one or the other, according to a follow-up OHSU study published at the end of January 2022.
“It makes no difference whether you get infected and then vaccinated, or if you get vaccinated and then a breakthrough infection,”?said Fikadu Tafesse, a coauthor of the study and a professor of molecular microbiology and immunology in the OHSU School of Medicine.
That said, the latest OHSU research is based on a fairly small pool of patients—a total of 104 OHSU employees who received the Pfizer vaccine. But the phenomenon of “super immunity” was also recently observed in South Africa, Dr. Jessica Justman, associate professor of medicine in epidemiology at Columbia Mailman School of Public Health, tells Fortune.
In other words, these are still preliminary findings, and many experts are looking for more data before drawing any concrete conclusions. And no one should purposely try to get a COVID infection in an attempt to boost their immunity. “The findings from both studies make sense to me, but it will take more time before we can say they are widely accepted,” Justman says.
Still, it’s helpful that initial studies show that having antibodies from a combination of vaccines and a natural COVID infection offers more protection than simply relying on antibodies generated from multiple, natural COVID infections, according to Dr. Luis Ostrosky, chief of the division of infectious diseases of the McGovern Medical School at the University of Texas Health Science Center at Houston. That’s because the antibodies generated from COVID infections can vary depending on each individual’s immune system.
“The natural infection immunity is robust for some people for some time, but it's not reliably durable,” Ostrosky tells Fortune, adding this immunity generally lasts about three months. And some people never actually gain immunity after their COVID infection.
“We've seen very clearly throughout the pandemic, people who have gotten infected with every single variant because, for some people, immunity never happens, or it's short-lived, and it's not reliable.”
That’s why Ostrosky says most medical experts have always said that vaccination is the best way to achieve immunity. Not only are there likely fewer hospitalizations and deaths, but the hybrid immunity built up through the combination of vaccines and breakthrough cases is proving to be stronger than immunity gained through natural infections.
“Many of us have sort of mixed feelings about what happened with Omicron because obviously, a lot of people are getting infected and just by sheer numbers, many people are in the hospital and dying, but this is building our herd immunity,” Ostrosky says.
Approximately 94% of people must be immune in order to achieve herd immunity and successfully halt transmission, according to the Mayo Clinic. With the stunning number of Omicron cases, health experts believe the U.S. could be on its way to hitting this target, although if that did happen, some experts have said it likely wouldn’t last for long.
A level of herd immunity is important because it can help the U.S. move from the pandemic stage of the COVID outbreak to more of an endemic stage, in which some normalcy returns because most of the population is immune, at least temporarily, from contracting COVID.
Yet when it comes to individuals achieving “super immunity,” it’s important to remember someone has to survive the breakthrough infection, Justman says. That is a real risk, especially for older people and those with medical conditions.
“Even for the majority who survive breakthrough infections, some have a rough time with severe acute symptoms and/or long-haul symptoms,” she adds.
The OHSU study’s authors do believe that this super immunity will be effective against other, future COVID variants, even as the virus continues to mutate. But the level of protection may change as more data emerges.
“I hope it is obvious, but you should not plan to get infected just to get hybrid immunity. It's a very dangerous situation. It is a deadly disease, after all, and there's nothing that guarantees that you do okay, if you get infected on purpose,” Ostrosky says.